|First appearance||"Pilot" (1.01)|
|Last appearance||"Time is Up for Today" (11.22)|
|Guest appearances||Maris: 2.15, 3.11, 4.17, 6.06, 18.07, 18.09, 18.21, 19.21, 20.15, 20.22, 21.17, 23.04, 23.22, 26.05|
Daphne Moon is a main character in the Frasier-based fan fiction spin-off Crane Life.
Daphne was born in Manchester, England, the only daughter in a large, working-class family of nine children; her accent, however, is not realistic of the region. She spent much of her childhood playing nurse and housemaid to her brothers.
She later moved to Seattle, Washington to pursue a career as a physical therapist. After several years working for Martin Crane, Daphne fell in love with Niles, eventually marrying him and having his child, David Crane, in the series finale of Frasier.
Daphne's eccentric qualities continue in Crane Life, and are often amplified: she remains convinced that she has psychic abilities and employs a sarcastic wit to deal with the equally odd characters that surround her.
Five years after Frasier, Daphne moves to Chicago, Illinois with Niles and their son when he gets a job at a prestigious psychiatric practice. Daphne is quick to settle in, and she is able to resume her work as a physical therapist for Stan Keenan. When Stan departs, Daphne's career is at a stand still for a short period before she joins Niles at the practice as a receptionist. Throughout the series, Daphne dabbles with the idea of becoming a psychiatrist herself but ultimately decides she is satisfied with her career choices.
Over the course of the series, Daphne becomes more accepting of Niles' flaws and their marriage remains mostly stable. At the end of Season 4, Daphne gives birth to Hester Crane, their second child, named in honor of Niles' mother. Towards the end of Season 6, Daphne begins to grow frustrated by the lack of communication in their marriage and departs for her native England for some time to think. Daphne ultimately realises she can't live without Niles and returns to the States. Their relationship grows stronger as a result of the separation.