|First appearance||"Pilot" (1.01)|
|Last appearance||"Time is Up for Today" (11.22)|
|Guest appearances||Maris: 2.03, 2.15, 3.11, 3.20, 4.17, 6.06, 8.12, 18.01, 18.07, 18.21, 19.21, 20.04, 20.15, 20.22, 22.13, 23.22, 28.15|
Dr. Niles Crane is a main character in the Frasier-based fan fiction spin-off Crane Life.
Niles was born in Seattle, Washington, in 1957, to Hester Crane, a psychiatrist, and Martin Crane, a police detective.
Niles' success in school led to his attendance at Yale University in New Haven, Connecticut as an undergraduate, and the Yale School of Medicine for both his M.D. and Ph.D. in psychiatry. He subsequently attended the University of Cambridge in Cambridge, England, where he was a postdoctoral fellow while completing his professional training.
In Frasier, Niles loved Daphne Moon from afar for many years. Daphne ultimately returned these feelings and they would wed a few years later. In the series finale, Daphne gave birth to Niles' first child, David Crane.
Niles spends most of the time in the show mediating the various complications at Mead Psychiatriy, a psychiatric practice in Chicago, while dealing with the typical chaos being married with children provides.
Throughout the first three seasons, Niles reluctantly acts as a mentor for trainee psychiatrists, among them are Dr. Sally Keenan and Dr. Jon Lloyd. After a rocky start at the practice in which he is forced to share an office with Dr. Will Casey, Niles ultimately grows to love the place and remains in a psychiatrist capacity for the duration of the series.
In Crane Life, Niles and Daphne's marriage continues to grow in ways unseen on Frasier. In Season 4, they have their first daughter together, Hester. Daphne becomes a lot more accepting of Niles' snobbery and eccentricities, and the two of them eventually develop a marriage which the other characters aspire to. Despite this, they run into a few problems during the series. At the end of Season 6, Daphne grows frustrated by the lack of communication between her and Niles, resulting in her leaving for England. After a few months away, Daphne returns, and she and Niles manage to settle their differences by electing to start all over again. As a result of this, their relationship grows much stronger and communicative.